Is it possible to set a preference in ChemDraw 16 so that when you modify an existing file and close it that it doesn't save it automatically? I haven't come across a solution so far.
ChemDraw used to prompt you and ask whether you wanted to save the file if you made changes. This was convenient if you changed something on accident and didn't notice, or only changed a structure to get a MW (but didn't want to modify your actual slide).